In cross-linking assays designed to measure disruption of substrate DNA binding, the photoprobes behaved similarly to a reference DKA inhibitor.
The effect of shift work, and circadian rhythm disruption, on reproductive outcomes is poorly understood, although advances have been made in the development of metrics for measuring disruption of circadian rhythm in working populations.
Animals were placed in one of the four activity boxes (40×40×40 cm) and horizontal and vertical activities were measured by disruption of infrared beams separated by 2.5 cm that cross the x y plane at two z-levels.
To analyse this hypothesis, we measured the disruption of the transmembrane mitochondrial potential (ΔΨm) using the fluorescent dye JC-1 in SH-EP cells after TRAIL/HDACIs treatments.
To test this hypothesis, we measured membrane disruption and quantified intracellular potassium levels in NLRP3-proficient and NLRP3-deficient macrophages that were treated with the GBS pigment.
Airspace injury was evaluated in a blinded fashion, by a semiquantitative method that measured alveolar disruption, neutrophilic infiltration, edema and hemorrhage as previously described [ 21, 22].
We measured the disruption of chromosome territories in MAA-fixed nuclei quantitatively by counting the number of independent objects in which the territories disintegrate when increasing thresholds were applied (Fig. 6f).
The GRIZLY assay detects stress-induced glucocorticoid production in single zebrafish larvae, measures disruption of glucocorticoid signaling by an organotin pollutant metabolite, and specifically identifies a compound stimulating endogenous glucocorticoid production in a chemical screen.
Social costs, which are difficult to measure, include "disruption to commercial and private traffic, increased traffic accidents, disruption of community and business access, noise, vibration and pollution," he said.
