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Moreover, prediction accuracy can be slightly improved by taking account of protein size information, as measured by sequence length descriptor 'L' and molecular weight descriptor 'W'.
It has been empirically demonstrated [ 22] that the number of common regulatory inputs of paralogous proteins decays with age since the duplication event (measured by sequence similarity of paralogs).
Networking versatility, which is indexed by k-core decomposition of the network, appears to be a notion properly reflecting the evolutionary adaptivity of domains, as measured by sequence and functional conservation.
This suggests earlier major speciation events in rabbits, associated with amplification of older families of TEs, consistent with phylogenetic analysis based on activities of SINE elements [ 70]. Figure 3 shows the number of different families of TEs in rabbit (yellow) and in pika (blue) for three different time intervals measured by sequence similarity to consensus.
By utilizing the DrugBank database, druggability of non-homologous essential proteins of E. coli O157 H7 was measured by sequence similarity to the targets of small-molecule drugs and BLASTP search was performed to align the non-homologous essential proteins to the list of drug-targeted proteins from DrugBank.
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Although measurements were unfortunately not available for all observations, promoter methylation measured by sequencing technology was more coincident (negatively correlated) with gene expression than by microarray.
Mature miRNA levels were measured by sequence-specific reverse transcription followed by real-time PCR using Taqman probes for detection.
Note also that the CAG repeat number measured by GeneMapper differs from that measured by sequencing.
Using these enrichment scores, we observed a greater dynamic range for common enriched regions measured by sequencing over those measured using microarrays (Figure S1).
The number of CAG repeats of R6/2 mice used in this study (N = 80) was 249±0.6 (mean ± SEM) as determined by GeneMapper (note that the CAG repeat number measured by GeneMapper differs from that measured by sequencing.
Let matrix A(N* M) represent known protein protein mappings measured by sequence-based similarities.
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