As brain accumulation could potentially be increased after boosting of oral taxanes with a P-gp inhibitor, we measured brain concentrations 2 h after oral administration of paclitaxel or docetaxel, that is, roughly around the plasma tmax.
Another alternative for directly measuring brain concentrations is measurement of 5-HT and its metabolites in samples of CSF acquired by lumbar puncture.
METHODS: Forty-five 3- to 4-year-old children with autism spectrum disorder (ASD), 13 children with typical development (TD), and 15 children with delayed development (DD) were studied using dual-echo proton echoplanar spectroscopic imaging (32 x 32 matrix-1 cm(3) voxels) to measure brain chemical concentrations and relaxation times.
Unfortunately, it is almost impossible to measure the brain concentration of an anaesthetic drug.
The maximum brain concentration measured was, on average, 155 ± 26 kBq mL−1 corresponding to 2.9 ± 0.5 nM [11C]AF150(S).
We measured plasma and brain concentrations of KD025 in male mice.
Compared to many other methods, microdialysis has the important advantage of measuring the free (ECF) brain concentration (6, 7).
Patients were reevaluated at 6-week intervals to measure change from baseline in several outcome measures, including right, left, and total hippocampal volumes, measured with magnetic resonance imaging; brain concentrations of N-acetylaspartate, measured with proton magnetic resonance spectroscopy; and cognition, assessed with the Alzheimer's Disease Assessment Scale cognitive subscale.
We measured plasma ammonia concentration, brain concentrations of glucose, lactate, pyruvate, glutamate and glutamine, and ICP.
Transport parameters from blood to interstitial fluid were either directly scaled up from the mouse study—referred to as the naive estimation or estimated using TMZ normal brain concentrations measured by intracerebral microdialysis in the same seven patients from whom plasma measurements were available.
