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To assess frailty, a measure of physiologic declines in multiple organ systems, in children with chronic liver disease using a novel pediatric frailty tool.
We chose heart rate as a measure of physiologic stress.
Frailty, a validated measure of physiologic reserve, predicts adverse health outcomes among adults with end-stage renal disease.
Cholinesterase monitoring has the advantage of providing a measure of physiologic response, but it is a less sensitive marker of exposure (He 1999).
Each component score provides a quantitative measure of physiologic function over 24 hours such that 0 represents normal function and 1, 2, 3, and 4 represent increasing physiologic derangement.
The advantage of the AL score is that it provides an integrated, biological measure of physiologic dysregulation due to chronic stress response, although it does not elucidate the dominant sources of chronic stress in the study population.
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Measures of physiologic sleepiness, as determined by the MSLT, also did not differ between groups [ 9].
Yet, many relevant measures of physiologic function in athletes remain unchanged compared to the general healthy population.
Repeatability is an important dimension because these measures of physiologic disturbance can then be tracked alongside fluctuations in delirium state.
Data on health-related quality of life, and measures of physiologic control, including blood pressure, anemia, calcium and phosphate metabolism and costs will be assessed as secondary outcomes.
Standard hemodynamic parameters such as blood pressure and heart rate are no longer regarded as the best measures of physiologic derangement in the critically ill trauma patient.
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