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Effective population size is driven by the strength of competition amongst parasites within a host and hence understanding the within- and between-host epidemiological processes is critical in order to determine an appropriate measure of pathogen fitness.
Aggressiveness: a quantitative measure of pathogen growth and development in the host.
In epidemiology, the basic reproductive number is a classical measure of pathogen fitness.
On the pathogen side, once infection occurs, aggressiveness is a quantitative component of measure of pathogen development on the host.
Pathogen aggressiveness is a measure of pathogen fitness and reflects the potential disease severity a pathogen can cause to its hosts.
Minor Criticisms Consider defining lifetime reproductive fitness of the symbiont as its between host net reproductive ratio, the commonly used measure of pathogen fitness.
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For example, multiple immune indices (i.e. the measured variables) could be used to estimate immune function (i.e. a latent variable) or several different "arms" of immune function (different latent variables for innate, acquired, etc).. Measures of pathogen richness and abundance could be similarly used to estimate pathogen pressure.
coli) are imperfect measures of pathogen exposure 21; although our results provide strong evidence that the intervention increased disinfection practices, our measures of E. coli could have overestimated the presence of diarrheagenic pathogens and thus health benefits of disinfection.
EcO157 present in agricultural environments are expected to be stressed, and possibly non-culturable, increasing the problem of measuring accurately the amount of pathogen in samples [31], [32].
Influenza-related death rates reflect the combination of 2 underlying epidemiologic parameters: the attack rate, a measure of a pathogen's transmissibility, and the case-fatality rate, a measure of a pathogen's virulence.
AUDPC was chosen because it summarizes disease intensity over time providing, at the same time, a quantitative measure of the pathogen virulence [ 55- 57].
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