None of the QOL measures showed meaningful differences between the CGM treatment and control groups after 26 weeks, although there was a suggestion of a QOL benefit favoring the CGM group on a few measures among adult participants.
They followed the same procedure as in Study 1, except that they did not complete the measure of intrinsic/extrinsic religiosity, given an absence of meaningful differences between these measures and the single-item religiosity measure (which was included here) in Study 1. Order of the passages and scales was again counterbalanced; no order effects emerged.
Notably, however, recent evidence has cast doubt on the ability of generic outcome measures to adequately capture meaningful differences in clinical severity for COPD patient populations.
An Urban Form index was adopted to determine that our measures of urban form capture meaningful differences in the characteristics of urban neighborhoods – differences that may have direct impacts on neighborhood vibrancy.
We find that our measures of urban form capture meaningful differences in the characters of urban neighborhoods that could well have direct impacts on the utility of urban residents.
Especially with regard to economic evaluations of newborn screening for inherited metabolic disorders, appropriate preference-based health outcomes which integrate mortality and morbidity in a single outcome measure should be used to value meaningful differences between MS/MS and alternatives in terms of health-related quality of life.
There were no significant differences between the age groups or significant treatment-by-age-group interaction for mean (SD) corrected QT interval (Fridericia's method) (younger: ATX, -1.0 [21.1] msec; PBO, 0.7 [16.3] msec; p =.510; older: ATX, -0.9 [18.1] msec; PBO, -1.1 [17.5] msec; p =.862; interaction p =.485), and no clinically meaningful differences in laboratory measures.
Thus, in all circumstances, the desired sample size of 1434 patients will be sufficient to detect clinically meaningful differences in the secondary measures of outcome.
However, when comparing regression coefficients across the five models using SUEST, no significant differences in meaningful differences between the various measures were found, pointing at similar responsiveness of the EQ-5D and the measures used for comparison.
A useful acceptance criterion, then, would distinguish operationally meaningful differences.
