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Ten different validated outcome measures were used to measure functional decline in the included 28 studies.
The diagnosis of dementia and mild cognitive impairment uses the Nottingham Instrumental Activities of Daily Living (IADL, with 0 indicating worst and 22 indicating best) to measure functional decline.
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Five different validated outcome measures were used with just over half of the cohort studies (n = 5) using the SF-36 or SF-12 as their measure of functional decline.
However, number of co-morbidities and ADL score as measures for functional decline can be regarded as proxy measures for illness severity as was corrected for in the logistic regression model.
The AORs for the interaction terms reflect the differential effects of the baseline functional status measures on functional decline across the four possible respondent status groups.
We also separately considered the association of three measures of functional decline between the first and second interviews with mortality.
Measures of functional decline were associated with increased risk of breast cancer mortality in overweight and obese women, but not in women of normal weight.
And, the effects of the baseline functional status measures on functional decline for participants who were self-respondents at both interviews and for those proxy-respondents at baseline who subsequently became self-respondents at the follow-up interview were not significantly different.
Main outcome measure Clinically important functional decline, defined as a functional deterioration of 5 points in five activities of daily living each scored from 0 to 3 (equivalent to one standard deviation decrease in functional ability).
This can be attributed to the variability in research designs and in the instruments used to measure comorbidity and functional decline, as well as to the relatively recent emergence of the concept of geriatric oncology.
2 5 6 Yet the prognostic value of individual limitations versus summary measures of physical functioning and functional decline remains poorly understood.
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