To assess skeletal maturity by measuring bone age (BA) in children with Cushing syndrome (CS) before and 1-year after transsphenoidal surgery or adrenalectomy, and to correlate BA with hormone levels and other measurements.
Measured bone age (BA) divided by chronologic age (CA) was used to assess standardized bone age (BA/CA).
Intraobserver reliability for the bone age measures was excellent (SE of measurement 0.10 years).
In the same patient cohort, ciclesonide also had no effect on skeletal maturity, as measured by chronologic to bone age ratio (Neffen et al. 2006).
However, delay in puberty is closely correlated with a delay in bone age, as measured on a wrist x-ray.
Daily oral medications, including glucocorticoids, mineralocorticoids, and salt supplements, are prescribed at the time of diagnosis in infancy and titrated according to blood levels of adrenal steroids, plasma renin activity, and electrolytes measured periodically, along with annual bone age x-rays.
4 Bone age, as a measure of skeletal maturity, can also be useful, although a delayed bone age (<2 standard deviations compared to the chronologic age) is nonspecific and associated with many different causes of short stature.
While difficult to measure, bone quality (alterations in bone geometry and microarchitecture) is also thought to be reduced with aging and contributes to compromised structural integrity of bone.
Bone age was determined according to the Greulich and Pyle method, and A1C levels were measured.
Also, bone scans actually measure bone formation, not the presence of cancer itself.
