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At the 2-year follow-up measurement (see below), items were added to measure adherence and subjective experience of adverse effects.
A 3-day self-report was used to measure adherence and a score ≥95 % was reported as adherent and <95%% reported as non-adherent.
However, the association between measure adherence and surgical outcomes is not well-established.
To explore how studies of decision aids conceptualize and measure adherence and to evaluate the effect of patient decision aids on adherence.
ASPs guide the clinician, measure adherence and performance, and ultimately benefit patients.
Eleven studies (58%) used MEMS to measure adherence, and 8 studies used pill count ratio.
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As it is impossible to control for every medication intake/application, patients need to be monitored by more or less crude subjective measurements as a generally accepted "gold standard" does not exist for measuring adherence and persistence.
We discuss the innovative nature of this trial and the challenges related to choice of patient population, maintaining masking, cost effectiveness, ethical considerations, measuring adherence, and placebo development and testing.
In what follows we first review the pros and cons of the main methods currently available (or being developed) for measuring adherence and related behaviour in vaginal microbicide and similar studies.
Despite their individual merits for measuring adherence and sensitive behaviour, none of these self-assessment techniques are capable of generating in-depth understanding of behaviours or reasons for behaviours.
Additionally, trials have differed in methodological factors including sample size, duration of intervention, primary outcome, method of measuring adherence, and follow-up after completion of the DAART intervention.
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