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We consider this an important finding as PLK1 silencing is already part of an integrated oncolytic adenovirus approach currently being studied in mice models of orthotopic gastric carcinoma [148] and has promise due to the lack of a reported measurable immune response of siRNA-based therapeutics [149].
Our goal in this study was to determine the highest dose of LT-B orally administered in mice that does not result in a measurable immune response.
A persistent and measurable immune response equal to or greater than that observed during natural infection was maintained through 5 years.
Serologic samples were excluded from statistical analyses if a person had reported illness within 14 days of sample collection because previous data suggested that 14 21 days is required for a measurable immune response (18 ).
150 Although the importance of these observations needs to be determined, future randomized studies of a gluten-free diet in people with various psychiatric disorders should be targeted at those with a measurable immune response to gluten.
These data point to an absence of geohelminth infection or of a measurable immune response to geohelminth infections (i.e. anti-Ascaris IgE) as being an important determinant of the strength of the association between HDM atopy and wheeze.
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However, measurable immune responses and control of tumor growth were achieved only by adopting complex protocols involving adoptive transfer of antigen-specific transgenic T cells and co-administration of anti-CD40, Flt3, GMCSF and/or CpG.
However, measurable immune responses and control of tumor growth were achieved only by an adoptive transfer of antigen-specific transgenic T cells and co-administration of anti-CD40, Flt3, GMCSF and/or CpG.
Conversely, clinical responses have been seen without the induction of measurable immune responses [ 40].
When harvested splenocytes were stimulated with whole virus antigens from clade 1 VN/1203, and from clade 2.3.1 IN5/05, respectively, very similar frequencies of IFN-γ-secreting CD4 T cells were observed, whereas stimulation with a H1N1 whole virus antigen revealed no measurable cellular immune response.
While specific antibody production has been detected in more recent experiments 15, vaccination also proved effective in absence of a measurable specific immune response 16, suggesting that mechanisms other than the classical adaptive immune response provide protection.
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measurable immune complex
measurable overall response
measurable physiological response
measurable clinical response
measurable functional response
measurable histological response
measurable genomic response
measurable transcriptional response
measurable proliferative response
measurable cytokine response
measurable haemodynamic response
monitored immune response
assessed immune response
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