This is partly due to the absence of measurable end points in this process.
Instead, the EPR is intended to answer refined phenotyping questions, with narrowly defined hypotheses and specific, measurable end points.
With increasing knowledge and practical experience, many of these tests have evolved into measurable end points in clinical research, applied as indicators of change, be it for the better or for the worse [ 10].
This BIF can be readily correlated with other measurable end points (e.g., collected at a higher level of biological organization through phenotypic changes) or used to generate testable hypotheses that could provide new insight into mechanisms of disease onset or progression.
This separation of inclusion formation from the molecular consequences of the Htt mutation is worthy of further investigation as many studies in in vitro systems use inclusion formation as a measurable end-point to assess the effects of potential therapeutics.
This mouse model provides an attractive platform that is amenable to interventional studies and chemoprevention preclinical trials, with easily measurable end-points for testing effectiveness of agents while providing tissue for correlative molecular studies.
Although in vitro bioassays cannot evaluate characteristics such as clearance and/or durability of fibers which may be critical determinants of fiber toxicity in lung, they can be used both to address dosimetry at the cellular level (i.e., number of fibers per cell that elicit a measurable biologic end point) and to evaluate preventive approaches to fiber-induced cell injury.
Maternal FT4 and TSH are the critical thyroidal parameters that endocrinologists are focused on as measurable thyroidal end points of concern, although there remains uncertainty over which of these is most important.
Blood pressure (BP) was chosen as an easily measurable and health relevant cardiovascular end point.
Because these weak bindings are transient events, they are not measurable by end-point assays that rely on the measurement of equilibrium binding state.
