In the absence of qualified entry-level workers, some companies have started using prison labour.In this workers' market, anyone with a measurable pulse and two fingers to peck at a keyboard is employable.
Central readers chose up to seven target tophi (five measurable tophi and two unmeasured tophi) for each patient for assessment throughout the study.
One patient withdrew his consent before enrolment, one had no appropriate measurable lesions, and two were misclassified when staging.
One patient was ineligible because they had no measurable disease, and two patients had only 8 days of treatment and no subsequent valid RECIST tumour assessments.
Eight patients were not evaluable for response: six had no radiologically measurable disease and two patients stopped treatment after only one cycle due to biliary stent infection and Hickman line infection, respectively.
Efficacy analysis showed no objective response in 15 patients with measurable disease, and six patients had SD.
Responses according to disease sites were one complete remission (CR) in peripheral blood, two PR in measurable targeted lesions, and two PR in skin lesions.
Ten patients were ineligible due to non-measurable disease and twelve patients because they had received prior chemotherapy.
Overall, 17 out of 22 patients had measurable liver disease, 12 out of 22 measurable lung disease and five out of 22 measurable lymph node disease.
"Risk is measurable, and composed of two parts: What could go wrong and what are the consequences?
