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It was expected that any means to inactivate the telomerase-mediated telomere elongation would provide an ideal anti-cancer therapy that specifically acts on cancer cells.
Harnessing gene editing to mutate cccDNA provides the means to inactivate HBV gene expression permanently.
Ingram highlights the under-appreciated work of David Wilson, who established during the 1940s that the scrapie agent was small and resisted conventional means to inactivate viruses.
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The Pentagon last week ordered a sweeping review of practices meant to inactivate the bacteria.
Tag is known to bind to and functionally inactivate both p53 and the pRb family of proteins, thus providing a means to simultaneously inhibit the tumor suppressor activities of these proteins.
However, the example of Cladosporium fulvum, which inactivates chitinases by Avr4 and thereby, protects its cell walls from degradation shows that vascular fungi have developed specific means to disarm plant defences [ 8].
Androgenesis (all-male inheritance) is generally induced by means of irradiating the eggs to inactivate the maternal genome, followed by fertilization with normal sperm.
Finally, the finding that loss of ALG-2 ameliorates all the effects of the premutation repeat means that therapies based on the ability to inactivate an Argonaute or an Argonaute-mediated event might be designed.
Using too many products often leads to irritation and can potentially cause ingredients to inactivate, since certain ones are not meant to be combined.
The reaction was heated to 95°C for 8 min to inactivate the proteinase K. Samples were purified by means of the DNeasy Tissue System kit (Qiagen, Chatsworth, CA, USA) before PCR.
The philosophy behind providing safe drinking water has always been a "multi-barrier" approach, which has meant starting with a clean water source, providing adequate treatment to remove particles, disinfecting the water to inactivate remaining pathogens, and maintaining a residual disinfectant to protect the water from the plant to people's homes.
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