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However, a substantial number of secretory proteins lack a classical signal peptide, called leaderless cargoes, and are released by unconventional means of secretion (Nickel and Rabouille, 2009; Nickel and Seedorf, 2008).
Then, considering the results previously obtained in mouse normal lung (Tourneur et al, 2008), we hypothesised that FADD release from human NSCLC could occur by the means of secretion.
In 1998, it was shown that Dictyostelium cells, known to be highly resistant to xenobiotics, get rid of Hoechst 33342 (HO342), a vital DNA stain for most cells, but not for D. discoideum cells, by means of secretion of extracellular vesicles embedding the dye.
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Mitochondria are also thought to stimulate insulin secretion by means of secretion-stimulatory intermediates that are generated by its intermediary metabolism.
We initially speculated that SAA3 could influence inflammation peripherally by means of its secretion into the bloodstream.
Also, a fusion protein including Gluc and yellow fluorescence protein (YFP) allowed visualization of the secretory pathway within cells, as well as serving as a means of monitoring secretion of luciferase activity.
PDC may enhance myeloid DC-mediated cross-presentation by means of IFNα secretion by PDC, which might favor this mechanism[23], but PDC's own ability to cross-present to CD8+ T cells is still a controversial and unresolved matter[24].
Finally, metabolic homeostasis also requires that organs coordinate their activities by means of the secretion of humoral factors or the propagation of nerve impulses between the organs.
The latter stimulates an adaptive cellular immune response, which by means of cytokine secretion and antibody production specifically eradicates pathogens and infected cells.
The mean volume of secretion in a 24 -hour period was 1,000 mL (500 1,500 mL).
Lichens, the rocks' first covering, aided the process of disintegration by means of acid secretions and made a lodging place for other life.
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