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Different strategies using tailed oligomers have recently been described as means of reprogramming alternative splicing decisions.
We previously described the use of tailed oligonucleotides as a means of reprogramming alternative pre-mRNA splicing in vitro and in vivo.
As a means of reprogramming splice site selection, we have used bifunctional oligos that hybridize to exon sequences and contain a tail designed to interfere with the use of a nearby 5' splice site.
Even though a cellular reprogramming clinical trial would likely be approached with caution, such an approach holds significant potential to materialize into relevant therapies while nongenetic means of reprogramming are actively being investigated.
In light of these previous studies, the large number of differentially up regulated genes in the myo1Δ strain together with the translational shutdown of others could represent a means of reprogramming gene expression to manage the chronic stress due to absence of myosin type II.
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The acquisition by the cancer cell of the necessary functional modules is achieved by means of genome reprogramming with the use of epigenetic machinery.
Means of enhancing reprogramming efficiency such as culturing in hypoxic conditions and using different methods of transfection are important should iPS be used in a therapeutic approach.
Mean values ± SD of the frequencies of reprogramming were calculated.
This functionally terminal phenotype increases the utility of TcBBM as a transient means to reprogram cells for regeneration of propagated plants that are not transgenic (non-GMO).
Genetic engineering is just another form of reprogramming.
Standardization was also a way of reprogramming life elsewhere in the default settings of the metropole.
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