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The initial idea was to perform a randomized controlled trial, in which the place of birth was decided for the women by means of randomization.
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The possibility of general effects was assessed by calculating the inbreeding coefficient (fixation index FIS) across loci in the population, thereby testing for a significant difference from zero (i.e. departure from a random union of gametes) by means of a randomization test in the program SPAGEDi 1.2e [37].
Allocation concealment will be maintained by means of central randomization.
Subjects were initially screened and assigned to the control or experimental groups by means of block randomization.
The split-plot design seems to be especially appropriate for simultaneously optimizing process and mixture variables of this chemical system facilitating operational procedures by means of block randomization.
Study design: Eighty-four withn windicationsions for induction of labor were assigned to receive either misoprostol 50 μg per vagina every 4 h as needed or 0.5 mg doses of dinoprostone given intra-cervically every 6 h by means of a randomization table generated by computer.
The boxplots show the distribution of the means of each randomization.
Finally, 1,757 patients were assigned to the Intervention Group (n = 867) or the Control Group (n = 890) by means of stratified randomization by centre and with concealment of allocation sequence.
Within the strata, patients will be randomly allocated to have computer-navigated MIS or the conventional THA procedure by means of cluster randomization to avoid interaction between both patient groups.
A computer was used to generate the allocation sequence by means of block-randomization.
There is a possibility of random error in the PD20AMP values, and to reduce the impact of spurious results at randomization, we used the mean of the randomization and screening visits values to define the baseline PD20AMP, in accordance with our protocol.
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