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In short, the efforts to-date are well intentioned but are more superficial than meaningfully effective.
The fact that the present meta-analysis, including 125 patients per group, did not achieve an effect size of this magnitude suggests again that the treatment approach is unlikely to be clinically meaningfully effective as assessed by these outcome measures.
In severe SSc, adequate prospective trials allowed investigators to ensure the safety of non-myeloablative autologous HSCT for SSc when careful patient selection, follow-up, and center effect are considered, to avoid misleading use of CY when it is unlikely to be clinically meaningfully effective.
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Instead of meaningfully scaling up effective treatment for people who became addicted to OxyContin, the major policy change was the removal of OxyContin by Purdue Pharma from the North American market in 2012 and its replacement with OxyNEO, which the company claims is tamper-resistant (i.e., harder to crush up, snort, or inject).
In the interim, we must finish making our charter workable, so it will meaningfully deliver independent and effective self-regulation.
These issues need to be meaningfully addressed when crafting effective immigration policy.
Together as a scientific community, we are committed to working together to optimize patient management, fully understand the science underlying AD, and develop effective treatments that meaningfully impact the course of disease.
The S.E.C. report, dated June 23, found that the exchange "has not meaningfully enforced the rule" since it became effective in 2001.
As most studies used multi component linkage interventions, this resulted in a large number of combinations, which made it difficult to meaningfully interpret which combinations were the most effective.
Children under the age of five or six do not yet realize that learning is most effective when new information is associated meaningfully with other knowledge.
Images will be more effective in the classroom if they are meaningfully integrated into course curricula.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com