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Furthermore, the two treatment regimens of decitabine from this study demonstrated significantly higher ORR [26.5% (CR, 9.8%; mCR, 16.7%)] than the minimal clinically meaningful threshold of 10%.
All three ORRs (3-day, 5-day, and total groups) were significantly higher than the minimal clinically meaningful threshold of 10% (Table 2)> -wrap-foot> P value calculated using single sample test using exact binomial proportion test, p 0 = 10%.
This reduction exceeds the clinically meaningful threshold of ≥0.3% proposed by the U.S. Food and Drug Administration for the development of new drugs for diabetes (29) and lies at the lower limit of efficacy expected for oral hypoglycemic agents (30).
Finally, the CDC recommendations are used in this study to provide a meaningful threshold of physical activity, but we acknowledge that these recommendations were developed principally for US populations.
Improvements in quality of life exceeded the clinically meaningful threshold of 10-points for all 5 SF-36 subscales in IA-BoNT/A group versus as opposed to only 1 subscale in the IA-placebo group.
Similar(55)
This limits the ability of clinicians to identify meaningful thresholds of cervical impairment, and to track quantitative changes in these impairments following treatment.
Our previous survey of Australian researchers found the median threshold (from 145 responses) of acceptable agreement for two hypothetical review panels assessing the same proposals was 75%; therefore, this level is a meaningful threshold for interpreting acceptable agreement.
Furthermore, for clinical or public health decision making, measuring classification accuracy (17) for a subset of meaningful thresholds for high risk might be more informative than the overall aROC.
Future work should also focus on identifying clinically meaningful thresholds for ChIMES scores to categorise the presence of mucositis and degree of severity.
The proportions of bootstrapped estimates lying outside of the meaningful threshold are in Table 1: only Type of assistance had >50% of the add-one estimates outside of the meaningful threshold.
The choice of estimator and of the meaningful threshold therefore clearly depend on the research question but should be defined and justified before analysis.
Related(20)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com