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Conversely, the smaller the number of locations (and therefore crimes) included, (a) the more likely the sample is to be biased in some way (Spatz Widom 1989, 160) and (b) the more difficult it is to conduct meaningful statistical tests (Brown 1989, 116).
The small sample size precludes capacity to undertake meaningful statistical tests and extrapolate to larger populations.
Although well suited to descriptively studying discussions, sample size prevented further exploration and meaningful statistical tests.
However, the adaptive permutation procedure was able to provide meaningful statistical tests for these SNPs, given the capacity to test for potential associations on rare or uncommon variants.
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In the current population as only four women reported being current smokers no meaningful statistical test could be performed to determine an effect in this group.
Third, this integrative assay identified a large enough group of CRCs with abnormal PTEN activity and presence to allow meaningful statistical testing of associations with dietary and lifestyle factors.
I hope the observed frequencies of various features, such as amino acids involved in RNA binding, and the size of the dataset will permit authors to perform meaningful statistical significance tests, Data presented in most of the Tables and Figures must be subjected to statistical significance tests.
Although numbers were too small for meaningful statistical significance testing or quantitative assessment of levels of agreement for each theme, we cross-tabulated the frequencies with which frontline service providers and Indigenous people mentioned each theme as an opportunity and/or a challenge.
The reviewers have concerns that this part of the study is not adequately documented in the data so that statistical tests are meaningful.
We caution against the mechanical application of statistical tests, however, and advocate for searching for substantive and meaningful significance, as well as statistical significance.
Rigorous statistical tests and control groups need be included to establish meaningful correlations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com