However, lack of sophistication in identifying the unique contribution of PI to the research process, together with lack of clarity around its implementation and practice made meaningful evaluation problematic.
Quantifying this in a meaningful way is problematic as these 3D-SIM images are all calculated reconstructions from multiple image stacks that, for technical reasons, have to be acquired sequentially (red first then green); the PCM is rapidly moving in these embryos making voxel by voxel comparisons unreliable, particularly in the crowded environment of the centrosome.
Resource-based, functioning-based, or primary-goods-based currencies of welfare, by contrast, may allow empirically meaningful and less morally problematic interpersonal comparisons.
5 Consequently, the geographic limits of epidemiological risk cannot be delimited accurately, 7 and planning meaningful control strategies becomes problematic.
This in-built relative dimension makes meaningful inter-country comparisons problematic when there are significant differences in the levels of intra-country income inequality.
As the importance of compliance to pulmonary rehabilitation had been documented and problematic, it was meaningful that participants complied 100% of the WBV intervention.
There does however need to be evidence that the psychometric characteristics of the PRO instrument are such that there is confidence that changes in scores over time with the application of treatments with some efficacy can be detected [ 10] and that the measurement error (or noise) is not so large that it is problematic to observe meaningful changes in patients' health status.
The relatively small number of probes (n = 434, unadjusted P < 0.05) tending towards significant differential expression immediately after exercise suggested that deriving meaningful functional information may be problematic given an expected false discovery rate of approximately 400 probes in this experiment.
In our opinion, obtaining meaningful FISH data will be problematic, as current FISH data measured compaction between fully inactive versus partially activated clusters (Chambeyron et al, Genes Dev 2004 and Morey et al, Development 2007), which is equivalent to our single versus bimodal organizations.
Both can be expressed in meaningful units (days/year), but both are problematic.
