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In 1972, when the National Institutes of Health introduced the National High Blood Pressure Education Program to help prevent hypertension, no meaningful experiments had yet been done.
These kind of questions need to be answered before meaningful experiments can be performed.
Distilling realistic SNP matrices from the haplotypes is crucial for designing meaningful experiments.
Continued development of HSIM and other stochastic automata and multi-agent systems should show that the dream of meaningful experiments in silico is not a pipedream.
Nevertheless, the CRP example demonstrates the potential usefulness of identifying coding variants through deep re-sequencing that may be taken forward into other meaningful experiments that specialize in function.
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However, the tree-level-view implies new conceptual and statistical challenges for a meaningful experiment evaluation.
We develop an analytical model of the viscoelastic behavior of this modified ECM, and design and implement a stretch test to quantify (based on statistically meaningful experiment data) the resulting changes in its stiffness induced by the external magnetic field.
Of course, it wasn't until later that I figured out that designing a meaningful experiment and getting your apparatus to work in psychoacoustics is just as challenging, but at the time, I thought, "Wow, if something opens up in this lab, then this is something I'd really enjoy thinking about and doing".
Moreover, we feel that examination of the adult-specific alae gaps is a more meaningful experiment (as suggested by the reviewers in the first review) since it is such a well-established phenotype linking persistent LIN-28 levels to defects in temporal cell fate patterning.
"We are seeing the limits of what a 'game' is being tested, we're part of a new wave of experiments in how interaction can produce meaningful experiences.
Less healthy, however, is the fashionable disparagement of "toy" domains: when properly approached, these domains can at the very least support meaningful systematic experiments, and allow features relevant to many kinds of reasoning to be abstracted and studied.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com