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It also renders meaningful data analysis next to impossible.
Such ambiguity severely limits meaningful data analysis and comparisons across studies, and delays the translation of the findings clinically.
If a large patient cohort is available for meaningful data analysis, a prospective randomized trial should be started in the future.
Sophisticated computational tools are available, but it is important to note that a basic understanding of these tools is required for meaningful data analysis.
Therefore, no formal sample size calculation was performed, although we aimed to recruit a sufficient number of patients to allow meaningful data analysis.
Information on human epidermal growth factor receptor 2 (HER2) amplification, stage at time of diagnosis and treatment was too frequently missing for a meaningful data analysis.
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A feasibility case must also ensure a signal-to-noise ratio (SNR) great enough to produce enough meaningful data for statistical analysis.
To extract meaningful data for further analysis, only miRNAs whose expressions were higher than 10 TPM at least in one of the datasets were selected.
In the present study, we used a combination of experimental design (long stimulation duration using CFS and meaningful sentences) and data analysis (MVPA) procedures, which has not been previously applied together.
18 Although the sample size of the South-East Asian population (n = 182) in our study was moderate, the corresponding sizes of the African-Caribbean (n = 30) and Middle-Eastern (n = 14) populations were very small for providing meaningful data on subgroup analysis for counselling women from those ethnic backgrounds, and a larger data set is needed for this purpose.
Instead of analyzing tens of thousands of gene comparisons, the network-based analysis offers a meaningful data reduction scheme that limits the analysis to only hundreds [ 14– 16] or even tens [ 17– 20] of relevant genes.
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