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We have chosen MCL since it has been shown to report meaningful clusters in biological networks [ 20].
We next tested whether disorders caused by mutations in different genes result in meaningful clusters in Clinical Face Phenotype Space.
While the two methods were comparable when using computational measures of evaluation, FBPA outperformed STEM in finding biologically meaningful clusters in both the irradiated and bystander cases.
For our future work, we are collaborating with biologists to explore the potential opportunities using our ASModel to identify biologically meaningful clusters in different species.
The proposed methods can be used by new biologists especially to cluster a large data set of proteins into meaningful clusters in order to detect their functions.
NaviClusterCS rapidly and automatically identifies biologically meaningful clusters in large networks, e.g., proteins sharing similar biological functions in protein-protein interaction networks.
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Standard psychiatric diagnoses are notoriously invalid - they do not correspond to meaningful clusters of symptoms in the real world, despite the obvious importance that they should.
Increasing the number of iterations does not produce additional meaningful clusters, resulting rather in a slightly decreased overall quality.
The evidence that CPBA identifies biologically meaningful clusters is readily apparent in the significant enrichment of MeSH categories in the disease clusters and in the significant enrichment of GO terms in the gene clusters.
Therefore, these full-dimensional clustering algorithms are not able to detect any meaningful clusters with the increase in dimensionality of the data.
The main goal of the analysis is to separate each magnetic resonance image in meaningful clusters, highlighting zones which are more probably related with the cancer evolution.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com