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Mean weight reductions of 3.35 kg versus 2.73 kg (P<0.001) and 3.77 kg versus 2.79 kg (P<0.001) were seen at day 7 in each trial with tolvaptan and placebo, respectively (Gheorghiade et al. 2007).
At 26 weeks, mean weight reductions from baseline were significantly (P<0.001) greater with both dulaglutide doses (−3.04 kg; SD, 3.48 with dulaglutide 1.5 mg; −2.65 kg; SD, 3.47 with dulaglutide 0.75 mg) than on sitagliptin 100 mg (−1.39 kg; SD, 3.54) and placebo (−1.42 kg; SD, 3.5).
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In addition, exenatide patients achieved significant mean weight reduction.
At 18 27 months, mean reduction in HbA1c was 0.5% and mean weight reduction was 5.5 kg.
Mean weight reduction of 0.8 kg was observed over the 4-week treatment period.
In our study, the mean weight reduction in patients with obesity or overweight was 1.78 kg (2.3 % of baseline weight).
Reporting of weight loss outcomes differed between studies and included mean weight reduction, percentage weight reduction or the percentage achieving a specified weight loss.
Mean weight reduction was 2.8 3.3 kg in the dapagliflozin groups compared with 2.2 kg in the control group.
Studies of exenatide once weekly demonstrated mean reductions in A1C ranging from −1.3% to −1.9% and mean weight reduction ranging from −2.0 kg to −3.7 kg [ 9- 16].
In terms of clinical relevance of the modifications we saw, the mean weight reduction at four months was limited (approximately 1 kg).
Meta-analysis of results from 13 clinical trials of diethylpropion indicate a mean weight reduction of 3.0 kg among obese individuals in studies of 6 52 weeks duration.
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