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There were absolute mean weight decreases from core study baseline to month 6 for all but the risperidone pre-switch antipsychotic medication subgroup (see Table 4).
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The patients' mean weight decreased significantly with Flexitouch™ use, but not with massage.
Mean weight decreased 1.2 kg with LY2605541 and increased 0.7 kg with insulin glargine (P < 0.001).
LS mean weight decreased by 4.1 kg and increased by 1.0 kg with PIA (P < 0.001).
Across all studies, mean weight decreased by 0.2 kg, compared with an expected increase of 3.5 kg.
In patients from the Middle East using antidiabetic comedication, mean weight decreased from 83.7 ± 15.5 kg to 82.2 ± 14.7 kg.
Mean weight decreased by 3.5 kg during run-in, then by 0.16 kg with insulin detemir or 0.95 kg without insulin detemir.
As a corollary effect of partial edema resolution, the patients' mean weight decreased significantly after Flexitouch™ (-2.3 ± 1.3 kg, P = 0.0002) but not after self-administered massage (+0.5 ± 0.9 kg, NS) [Figure 5].
In the range of short distances (below 40 mm), the plot follows a similar behavior as the reshuffled data set, while for longer distances the mean edge weight decreases very slowly.
Mean body weight decreases after about 60 years [ 3, 4], largely due to a loss of muscle mass [ 5].
Mean body weight decreases were greater with all dapagliflozin doses than with placebo, although they did not reach statistical significance (Fig. 3 C, Table 2).
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