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At 1 year, mean weight changes in the groups were -3·26 kg (brief intervention), -4·75 kg (12-week programme), and -6·76 kg (52-week programme).
Mean weight changes were −1.6% with placebo, −5.1% with low-dose PHEN/TPM, and −10.9% with full-dose PHEN/TPM.
In our opinion, these categorical analyses provide information that is clinically more useful than analyses based on mean weight changes.
The corresponding mean weight changes in kilograms were -2.1 kg, 0.9 kg, and 4.6 kg, for lost, stable, and increased weight groups, respectively.
7 9 13 There is also lack of agreement on which outcomes to publish with some studies reporting mean weight changes, proportional weight loss or absolute weight loss.
46 Mean weight changes in the placebo, mid-dose PHEN/TPM, and full-dose PHEN/TPM groups were −1.2%, −7.8%, and −9.8%, respectively.
Similar(48)
Among more recent studies, mean weight change over one year in one double-blind study of lithium-treated patients was 4.2 kg (Calabrese et al. 2003).
37 After 26 weeks of therapy, mean weight changed from baseline by −2.0 kg in the EQW group compared with −0.8 kg in the sitagliptin group (P<0.001).
Across all these programs, mean weight change after 12 months among about 77% of total participants with follow-up data were −3.99%9595% CI −5.16 to −2.83).
Similar findings were found in an analysis of weight change post-transplant in a comparable population of 156 transplant recipients in Brisbane, Australia (mean weight change 3.3 kg, SD 6.0 kg) (Campbell KL, personal communication) [ 18].
At week 8, mean weight change was as follows: placebo +0.3 kg, APZ 5 mg/day +1.3 kg, APZ 10 mg/day +1.3 kg, and APZ 15 mg/day +1.5 kg; all p < 0.05 versus placebo.
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