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Given the higher degree of contraction of A2-BRLF-1 CD8+ T cells (48.7-fold decrease in mean values) following AIM, and prior reports that PD-1 expression is significantly correlated with contraction, it was surprising to find that the intensity of PD-1 expression was lower than that of A2-BMLF-1 CD8+ T cells both in AIM and convalescence.
We calculated absolute annual trends for both data sets using a general least squares regression of 5-month box-car filtered (i.e., median of ± 5 months from the center date), deseasonalized monthly mean values following Zhang and Reid (2010).
IL line mean values for normally distributed traits (DPS, EARN, GDU, INDL, PH and PNDBE) were compared with the B73 mean values following a two-sided Dunnet's test as implemented in Statistica 8.0 (StatSoft, Inc ., with an alpha level of 0.05, while for non-normally distributed traits (ND, NDBE and NDAE) a Steel's test was carried out as implemented in GenStat11.
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Untreated NPC patients had a mean IL-6 concentration of 164 ± 37 pg/mL, which was significantly higher than the mean value following treatment (58 ± 16 g/mL; F 2,138) = 7.534, p < 0.01).
In contrast, the mean LDPI values following acepromazine (group 1) and dexmedetomidine administration (group 2) differed significantly.
18 Published steady-state mean (range) Cmin values, following administration of the approved monthly intravenous dose, are 24 (1–66) µg/mL.
Figure 4 shows all the observed ANC values and population-predicted ANC time profile (i.e., PRED vs time corresponding to the mean system-related parameters and Slope values following the mean docetaxel dose of 150 mg).
Plots of the mean increase in R1p values, following intravenous injection of Gd-DTPA, in EL-4, progressive E.G7-OVA and regressive E.G7-OVA tumours, are shown in Figure 4.
Post hoc analysis demonstrated that there were significantly higher PPT values following Ipsi-R (Mean Difference [MD] = 24.6 ± 6.9 %, p = 0.006, ES = 0.7) and Contra-R (MD = 21.8 ± 7.0 %, p = 0.02, ES = 1.0) compared with the Control group.
VAS values following RT were recorded as the mean value for the week.
Following the Trinity protocol [ 64], expression normalization was calculated using TMM (trimmed mean of M-values), following FPKM (fragments per feature kilobase per million reads mapped) calculations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com