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Neither the TD/TI nor the TT/3R methods are useful since there is a lack of normal values, a gold standard and numerous mean values exist for the described methods.
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Figure 6 shows that large differences of FST values exist among disease classes, while mean FST values are usually higher than those of non associated genes.
Do "secular values" exist at all?
When multiple values existed, the mean value in the year of first ulceration was used.
If no valid values existed, the group mean was used.
No variable had more than 5% missing values; where missing values existed, they were inputed using the relevant mean [33].
Then, means of all values of the same gene generated by different probes were calculated, if at least three values existed excluding outliers.
By the Mean Value Theorem, there exist and where, such that (6.4).
Therefore, by the integral mean value theorem, there exist x 0 ∈ K and y 0 ∈ L such that ρ K − x 0 p ( u ) 1 V ( K ) ∫ K d x ≤ ρ L − y 0 p ( u ) 1 V ( L ) ∫ L d y, thus ρ K − x 0 p ( u ) ≤ ρ L − y 0 p ( u ). for all u ∈ S n − 1.
In the comparison among categories, there was a progressive worsening of mean values, and statistical significance existed between Groups I and IV.
By the integral mean value theorem, there exists such that (3.22).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com