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The mean trough values increased over time towards the steady state.
Final visit mean trough values were 0.2 ± 0.1 μg/mL for monthly responders and undetectable for the monthly nonresponders.
Mean trough values ranged from 0.6 to 0.7 μg/mL for biweekly responders and below 0.05 μg/mL for biweekly nonresponders at all time points.
Mean trough values were 11 to 12 ng/mL after the starting dose and 11 to 16 ng/mL after maintenance dosing of 80 mg/month (at a concentration of 20 mg/mL).
Similar(56)
The mean Cmax and Cmin (trough) values of micafungin in plasma were 6.31 ± 1.08 and 1.65 ± 0.54 μg/mL, respectively.
There was no statistical difference in the mean elimination rate or the trough values for both regimens (half-life 4.767 hours versus 4.771 hours and trough levels of 143 ng/mL versus 124 ng/mL).
The pharmacokinetic and pharmacodynamic parameters of vancomycin in survivors and nonsurvivors are summarized in Table 2. Notably, the mean trough and peak concentrations, calculated AUC values, and clearance of vancomycin did not differ significantly between the two groups (Table 2).
In rhesus macaques receiving 125 mg of aprepitant daily, the mean trough concentration at steady state was 2.66 ± 1.55 μg/ml, with a maximum value of 16 18 μg/ml [ 47, 49].
The mean trough serum level was 0.50 ± 0.29 mg/l.
Primary endpoint: mean trough FEV1 at Day 28.
Subsequent analysis was performed utilising only the trough values.
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