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Mean trough plasma concentrations were similar for generic and brand lamivudine and stavudine, but trough nevirapine concentrations were significantly higher with the generic formulation during period 2 (Table 2).
The primary objective was to compare the mean trough plasma NVP levels between the two groups.
The mean trough plasma levels of dexverapamil and its major metabolite nor-dexverapamil were 1.2 and 1.5 microM respectively.
The mean trough plasma concentration at 3 months was 2205 pg ml−1 (range 678 6166 pg ml−1).
Mean trough plasma NVP level in group A was also significantly lower than that in each subset of group B patients (P < 0.001).
Instead, mean plasma profiles showed relatively stable rotigotine concentrations after multiple dosages (Fig. 4), and mean trough plasma concentration remained stable over the treatment period.
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70 The average trough plasma rilpivirine concentration was 52 ng/mL two weeks after switching therapy.
70 For weeks 4 12, the average trough plasma rilpivirine concentration was 66 84 ng/mL.
We found a median trough plasma concentration of 134.3 mg/L (IQR 65.3 201 mg/L).
The median trough plasma concentration ranges of sunitinib and SU12662 across treatment cycles were 31 56 and 11 18 ng ml 1, respectively.
Mean trough and peak plasma levels were calculated for 4 days of therapy.
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