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In this case, mean trough levels were determined to be < 100 ng/mL, which is not expected to interfere with ADA detection at 75- to 750-fold dilution of the surrogate of polyclonal PC.
Mean trough levels of free VEGF were ∼14.4 pg/mL, compared with a baseline of 17 pg/mL.
Between weeks 9 and 49, the mean trough levels varied by <18%, which indicates that denosumab pharmacokinetics did not change over time or with multiple dosing.
Mean daily dose of LCPT was significantly (p < 0.0001) lower than preconversion tacrolimus dose at each visit; mean trough levels between groups were similar.
In the OD group, mean trough levels remained at 9.64 μg/ml from days 2 to 4 and peak levels remained at a mean of 24.84 μg/ml.
The mean trough levels of tacrolimus for these 7 patients were 6.11 ± 2.02 ng/mL before conversion and decreased to 3.04 ± 1.12 ng/mL when acute rejection was suspected.
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Vancomycin-treated patients had a mean trough level of 13 ± 8 μg/mL at day 3.
Before conversion, the mean trough level of tacrolimus was 5.26 ± 2.12 ng/mL.
Mean free (unbound) VEGF levels with ranibizumab were largely unchanged, with mean trough level of 14.4 pg/mL compared with baseline of 17 pg/mL.
The mean linezolid serum concentration peak (Cmax) was 15.32 ± 3.98 μg/ml, and the mean trough level (Cmin) was 1.87 ± 1.70 μg/ml.
After one month of tacrolimus formulation conversion, the mean trough level of tacrolimus was 4.38 ± 2.21 ng/mL, which was significantly lower than that before conversion (P < 0.001).
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