Sentence examples for mean trough concentrations from inspiring English sources
Mean trough concentrations of linagliptin were similar across visits (ranging from ∼7 to 10 nmol/L).
The ratio of mean trough concentrations of tacrolimus after comparison with before conversion was 1.02 (90% confidence interval 0.95 1.09).
Mean trough concentrations after the second ziv-aflibercept dose plateaued and remained at ∼10 mg l−1.
Based on visual inspection of the mean trough concentrations of selexipag and ACT-333679, concentrations on Day 8 were at steady state (data not shown).
For example, in one of these studies, the mean trough concentrations of i.m. fulvestrant were found to be 6.1 ng ml−1 after 6 months of fulvestrant 250 mg treatment compared with 2.8 ng ml−1 after the first month (Robertson and Harrison, 2001).
Following multiple infusions of olaratumab at 10 mg/kg q3w and 20 mg/kg q2w, the geometric mean trough concentrations (Clast) were close to or above the target trough concentration (155 μg/mL) associated with antitumor activity in preclinical xenograft studies.
The mean trough concentration ratio of Day 85 (14 days after the last dose) to Day 15 (14 days after the first dose) was 1.79, indicating a mild exposure accumulation.
The geometric mean trough concentration (Cmin) of BMS-936557 increased from 42.2 µg/ml on Day 15 to 91.3 µg/ml at steady-state on Day 57.
This estimated time to reach steady state corresponds with phase 2 data that showed a steady state after approximately 8 days, as the mean trough concentration at day 8 was similar to the mean trough concentration after 4 weeks of treatment.
Although the mean trough concentration at day 2 of treatment was slightly higher than reported in healthy humans [ 21] and exceeded 1.0 μg/mL in 75% of patients, it failed to reach this target concentration in 25% of them [ 18].
These initial dose-ranging studies demonstrated that, for FK506, the ideal human-relevant dosage was 1 mg/kg i.p. daily (mean trough concentration 6.9 ng/ml, s.e.m. 0.58; Fig. 2).
