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The effect of the extract on the mean stool score and number of wet feces is shown in Table 2.
200 and 400 mg/kg doses of the extract were superior in reducing mean stool score and number of wet stools, respectively.
Meanwhile, the standard drug showed a marked reduction in both fecal outputs produced by castor oil and mean stool score by about 65%and84%4%, respectively.
In castor oil induced diarrhea model, the extract dose produced a significant reduction in mean stool score (1.94 ± 0.102) at 200 mg/kg.
Similarly, the extract demonstrated a significant reduction of mean stool score that indicated change of stool consistency from watery to solid stool.
After 30 min of the administration of castor oil, all the animals of the negative control group (2% TW-80 treated) were apparently diarrheic with a mean stool score of 2.68 ± 0.05 out of 3 scale stool score.
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The breastfed infants also had softer stools, with significantly higher mean stool consistency scores at both 6 weeks postnatal (2.4, 1.9, and 1.9, respectively, p < 0.05) and 12 weeks postnatal (2.4, 2.0, and 2.0, respectively, p < 0.05).
For prespecified primary and secondary endpoints, mean stool frequency and rectal bleeding scores were derived from values recorded in the 7 days prior to the study visit.
The DAI score was calculated as the sum of the diarrheal score and the bloody stool score as follows: 0 = normal stool and normal-colored stool, 1 = mildly soft stool and brown stool, 2 = very soft stool and reddish stool, and 3 = watery stool and bloody stool.
Mean stool weight, stool fat and stool nitrogen (g/day) were determined from the net weight/fat/nitrogen in the 72-h stool sample.
Patients receiving pancreatin also had a significantly greater improvement in nitrogen absorption (CNA) compared with placebo, and greater reductions in mean stool fat, stool frequency and stool weight.
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