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Daytime hypersomnolence, diagnosed by mean sleep latency on the MSLT ≤ 10 minutes.
No significant correlation existed between the ESS or PSQI results and mean sleep latency on the MSLT.
Results: Mean sleep latency was ≤ 10 minutes in 47% of the cohort and ≤ 5 minutes in 18.3%.
The ESS scores correlated significantly with mean sleep latency in the multiple sleep latency tests in some studies [33, 43, 45], while others show no significant association [46 48].
No significant correlations were found between the ESS score or mean sleep latency and hypocretin autoAbs after correction for multiple tests.
It should be noted that 15 patients out of 26 affected with HI presented mean sleep latency below 8 minutes on the MSLT.
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The study showed significant decrease in the mean sleep latencies of the MSLT in GBS patients compared to control (11.8 ± 4 versus 16.6 ± 2.2 with p value 0.002).
All subjects were submitted to one-night polysomnogram (PSG) followed in the next day by multiple sleep latency test (MSLT) to assess the mean sleep latencies (objective parameter measuring excessive daytime sleepiness).
The study also showed that motor deficits measured by the ODSS were not correlated with the patients' age, HAS, MADRS, mean sleep latencies of the MSLT, and other examined PSG parameters (Table 3).
The mean sleep latencies of MSLT were significantly shortened and PSG showed shortening of the total sleep time, sleep efficiency, lowest O2 saturation and pulse transit time with increased wake after sleep onset, sleep stage transition index, apnea hypopnea index, desaturation index, arousal index, snore index and periodic limb movement index.
Patients were evaluated initially before immunotherapy using the Overall Disability Sum Score (ODSS), Neuropathy Pain Scale (NPS), Hamilton Anxiety Scale (HAS), Montgomery Åsberg Depression Rating Scale (MADRS) and one-night polysomnography (PSG) followed by the multiple sleep latency test (MSLT) to evaluate the mean sleep latencies.
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