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In longitudinal analysis, the highest urine cotinine tertile was associated with greater dyspnea (mean score increment 0.9 points; 95% CI 0.2 to 1.6).
The highest cotinine level also appeared to be associated with worse COPD severity (mean score increment 4.7 points; 95% CI -0.1 to 9.4 points; p = 0.054), physical health status (-5.7 points; 95% CI -14 to 2.0 points), and disease-specific QOL (mean score increment 2.9 points (-0.16 to 5.9 points).
In cross-sectional analysis, self-reported lower level SHS exposure (1 3 hours) was associated with poorer disease-specific QOL (mean score increment 3.6 points; 95% CI 0.4 to 6.7 points) and dyspnea (mean score increment 1.1 points; 95% CI 0.3 to 1.8) after controlling for covariates (Table 3).
The highest urine cotinine tertile was associated, in cross-sectional multivariate analysis, with poorer COPD severity scores (mean score increment 4.7 points; 95% CI 0.6 to 8.9 points) and MRC dyspnea scores (score increment 1.0; 95% CI 0.4 to 1.7 points) (Table 4).
The highest level of SHS exposure, as measured by urine cotinine, was cross-sectionally associated with poorer COPD severity (mean score increment 4.7 pts; 95% CI 0.6 to 8.9) and dyspnea (1.0 pts; 95% CI 0.4 to 1.7) after controlling for covariates.
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