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Exact(5)
A similar nonlinear pattern in mean risk is observed for both of these scenarios.
The pattern is nonlinear: The decrease in mean risk is larger for small barrier depths compared with large barrier depths.
Compared with one digester, the mean risk is lower for the two digesters (2 × 10−4 vs. 1 × 10−3).
The estimated odds ratio is similar to the hazard ratio if the mean risk is small, but the odds ratio increasingly overestimates the hazard ratio as the mean risk increases.
For men between the 75th and 85th centile - 10% of the population - true mean risk is only 22%, considerably less than that estimated by the quantile approach; for patients in the top 5%, true risk is 54%, nearly double the risk of the highest quartile as a whole.
Similar(53)
The cost of certain speculative financial instruments for businesses might be higher because there would no longer be the guarantee of a taxpayer bailout of the bank if things went wrong, but the cost increase would simply mean risk was being correctly priced.
Under this exposure scenario, the mean risk was 2 × 10−2.
The mean risk was calculated from the model containing both covariates.
The reclassification and clinical utility measures showed similar relationships with mean risk when the mean risk was less than the cutpoint and the baseline model was not strong.
For datasets where the mean risk was near or above the cutpoint, a higher proportion were classified as high risk by the baseline model.
When mean risk was higher than the cutpoint, the two measures dropped with the difference in Net Benefit approaching zero with increasing risk.
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Justyna Jupowicz-Kozak
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