Exact(9)
The proportion censored decreased from 10% to approximately 2.5% as the mean risk increased.
As with NRI binary the NRI(10%, 20%) approached zero as the mean risk increased.
As the mean risk increased there was a small increase in the difference in the c-statistic.
Although in the simulated datasets the hazard ratio was constant as the mean risk increased, the odds ratio increased.
However, we observed a divergence in the clinical utility measures in our simulations as the mean risk increased.
In our simulations we observed that as the mean risk increased the NRI >0), and the change in the c-statistic, also increased.
Similar(51)
Our simulations, where we assumed a constant hazard rate, indicate that the NRI >0) increases as the event rate (the mean risk) increases for event rates above the cutpoint.
Similarly, as the wind speed increases, the attenuation decreases and therefore the mean risk increases.
The estimated odds ratio is similar to the hazard ratio if the mean risk is small, but the odds ratio increasingly overestimates the hazard ratio as the mean risk increases.
The continuous NRI increases with increasing mean risk; the NRI categorical with two cutpoints often peaks at two points; whereas the net Benefit and EFLY peak once close to the cutpoint and then generally decrease to zero as the mean risk increases.
After 4 months, the control group experienced an insignificant decrease in predicted 10-year CHD risk; at 12 months, mean CHD risk increased ∼2% over baseline (P = 0.073).
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