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The frequency of oscillation for the mean response at different locations shown in Figs. 2, 3, and 4 are not varying as the vehicle wheel is excited by same frequency due to uniform velocity considered in the presentation of the results here.
Hence, f(x) describes the mean response at concentration x (>0).
The main effect of time examines the mean response at each time point averaged across drugs, and the drug multiplied by time interaction examines whether the change over time differs between drugs.
Although the simulations do not fully recapitulate the apparent higher mean response at the lower dose, the apparent numerical difference on the observed mean PANSS improvements at 100 and 200 mg b.i.d. of vabicaserin was likely an artifact of data variability.
To account for such instances in the data, we excluded tuning curves for which the mean response at the largest gradient heading was not significantly different (t-test; p ≤ 0.05) from the responses of its immediate neighboring headings (29/360 total tuning curves from 72 cells).
The NRC, in their examination of the Faroe Islands cohort study, the study on which they place greatest reliance, stated that "[b]ecause these calculations necessitate extrapolating to estimate the mean response at zero exposure level," logarithmic models "lead to lower estimates of the Benchmark Dose (BMD) than linear or K-power models" (NRC 2000, p. 294).
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In many toxicological assays, interactions between primary and secondary effects may cause a downturn in mean responses at high doses.
Although this could be interpreted as modest impairment, it is important to note that these mean responses at the domain or total level do not capture dispersion, and are likely to conceal high individual item scores of potential clinical significance.
We also sought to perform an analysis of the mean response levels at the level of individual participants.
A T group is said to show memory retention when its mean response level at test trial is statistically lower than that of the respective U group.
EJP amplitude histograms were constructed by averaging 50 separate events stimulated at 0.2 Hz from an individual muscle cell and then calculating the mean response from at least six larvae per line.
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