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The mean repeat number in patients is estimated to be 63 68 repeats.
The mean repeat number was 9 and the mean repeat length was 23 bp.
The variance and mean repeat number in a population will then reflect susceptibilities for each disease and their fitness costs, which must therefore be interpreted in the physiological, geographical, and ecological context in which they have, and presumably are, evolving.
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Mean repeat numbers ranged from 4 to 23 (repeats/microsatellite type) for the PGS species and between 4 and 86 repeats for the WGS species.
The mean CAG repeat number is almost identical between the cases (18.74±0.13) and controls (18.73±0.12), while the median value is same (19 repeats) for both.
A relative risk of 1.1 (95% CI 0.5 2.6) was observed for women with 28 or more CAG repeats from a pooled analysis of 188 BRCandand BRCA2 mutation carriers [ 8], whereas a study of 227 BRCandand BRCA2 mutation carriers reported shorter mean CAG repeat number in women with breast cancer diagnosed before age 42 years as compared with those diagnosed after this age [ 9].
These findings suggest that susceptibility to colon cancer is associated with both longer and shorter AR CAGn, depending on gender, which correspond to ethnic level differences in mean AR CAG repeat number.
The protective effects of shorter AR CAGn in men versus the increased risk of disease in women means that optimal repeat number for AR CAGn with respect to colon cancer alone may differ for each sex.
Additional microsatellite statistics (number of alleles; mean and variance of repeat number; and heterozygosity) were calculated using Microsatellite Analyzer (MSA) v4.05[ 16].
For every motif size (mono-, di-, tri-, and tetra-) and repeat number bin, the mean and median recombination rates of all TRs in the bin were computed.
Figure 2 presents mean polymorphism indexes for perfect microsatellites across four repeat number classes.
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