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The mean reductions from baseline systolic and diastolic blood pressure at 8 weeks were 16.7 and 12.1 mmHg, respectively.
Mean reductions from baseline in seated in-office BP were somewhat greater for the dapagliflozin group than for the hydrochlorothiazide group.
In the hyperlipidemia analysis, colesevelam versus placebo produced similar mean reductions from baseline in LDL-C in older (−16.6 vs. +0.5 %) and younger (−13.7 vs. +0.4 %) patients.
For patients maintained on SC abatacept during period II, mean reductions from baseline seen in period I were maintained through periods II and III (figure 3C).
In both studies, small mean reductions from baseline IOP were observed in the bimatoprost and vehicle groups but were not clinically significant.
Both regimens improved HbA1c levels during the study, with overall mean reductions from baseline to week 26 of −0.99% and −1.02% for the twice and three times daily regimens, respectively.
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Mean reduction from baseline IOP with bimatoprost BID was not significantly different from that with timolol at month 24 at 10 am (P = .474).474
Bimatoprost QD provided significantly greater mean reduction from baseline IOP than did timolol at both measurements at each study visit (P≤.001).
A pooled analysis showed that adding colesevelam HCl to statin therapy significantly lowered LDL cholesterol levels (21 mg/dl or 16% mean reduction from baseline, p = 0.0013, and 11 mg/dl or 9% mean reduction compared with placebo, p = 0.0003).
At 10 am (peak timolol effect) at month 24, the mean reduction from baseline IOP was 7.8 mm Hg with bimatoprost QD and 4.6 mm Hg with timolol (P<.001).
The overall mean reduction in bone height was 2.72 ± 1.27 mm: (i) the mean reduction from immediately after surgery to 6 months afterward was 1.28 ± 1.05 mm and (ii) that from 6 months after surgery to 2.5 years after surgery was 1.44 ± 1.45 mm (Table 6, Fig. 6).
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