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Mean (range) administered dosages were 1.39 (0.86 -2.16) mg/kg for a median (range) of 12 (0–15) days.
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36 Topotecan CLss was similar over the dose range administered.
*Median (range); #mean (range); ns, not specified.
*mean ± standard deviation or mean (range).
Corrected for shunting to the lungs (mean 7.4%%; range 3.0 13.0 %), the mean administered amount of Ho-PLLA-MS to the liver was 484 mg (range 408 593 mg; Table 1).-wrap> Ho-PLLA-MS caused enhanced MR signal decay after administration, translating into high R2* values (Fig. 1).
When analyzed, the mean volumes administered were similar: JUP 1.17 mL (range 0.6 1.6 mL) and PER 1.13 mL (range 0.6 2.0 mL; P = 0.22).
We then calculated for every dose-level: the mean dose administered at each dose level, its standard derivation, the median and the range.
All patients received CBC, renal and liver function tests the day before and 2 days after application (mean administered activity 5.6 GBq, range 4.1 6.1 GBq), followed by further tests every 2 weeks.
The mean dose administered was 1.2 mg.
Another feature was the high dosage of vasopressin (mean 73.3 [± 30.1] IU, range 20-100 IU) administered to the intervention group.
The mean administered activity was 141 ± 8 MBq (range, 133 to 148 MBq).
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