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A threshold chosen to be 1 percent of the maximum mean protein levels was computed.
Considering the fact that the mean protein levels are higher in the Delay circuit populations (Fig. 8(A)), its higher CV in Figure 9 clearly shows that variability in the Delay circuit population is considerably higher compared to the Basic circuit during the time of the build-up of the overshoot (till 90 minutes).
<img src="http://journals.plos.org/plosone/article/asset?id=info?doi/10.1371/journal.pone.0015003.e006.PNG" class= inline-graphic"/> where x is an n-component vector of protein levels, µ is an n-component vector of mean protein levels, Σ is the n x n covariance matrix and |Σ| and Σ−1 are its determinant and inverse.
To perform the fitting, we set the population mean protein levels P0 to the wildtype levels (Li and Hazelbauer, 2004) except where noted below to match the experiment.
No differences were found when comparing mean protein levels of CYP2C8, CYP2E1, CYP3A4, and CYP3A5 measured in normal and neoplastic tissue of patients with adenoma.
Since the mean of a gamma distribution is equal to kθ, the θ parameter of each gamma distribution was changed as needed to attain the desired distribution mean (see Table 1 for values of mean protein levels).
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We find that the mean protein level increases over the cell cycle.
The two parameters that define the Gamma distribution (a and b), corresponding to the mean protein level and the noise strength, vary over time (Figure 6C).
This was achieved through increasing the rate of comK gene transcription and simultaneously reducing the translation rate by an equal amount so that the mean protein level remains the same.
The mean protein level of IGF-1R in the HRT users was 134% of the mean value of their nonusing co-twins (n = 9 pairs, P = 0.039).
Variation in the parameter values within these ranges leads to significant variation in protein abundance (e.g. a range of 106 in the mean protein level).
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