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In women Also women suffering from premenstrual mastodynia have supraphysiologic high prolactin pulses resulting premenstrually in supraphysiologic mean prolactin levels (Fig. 1 and 2).
Owing to the differences in average prolactin levels and cycling patterns, we presented data on mean prolactin levels by genotype stratified by menopausal status.
Non-responders had higher mean prolactin levels on treatment (prolactin less than 500 mIUl-1 in 14/40 NR, 2/35 R, P less than 0.01).
Geometric mean prolactin levels were estimated using linear regression models adjusted for age, study site, blood collection time, and menstrual cycle day (premenopausal women).
Mean prolactin levels during 10 30 mg daily treatment with olanzapine are approximately 17 ng/ml, which is higher than that of normals, drug-free patients and clozapine-treated patients [ 28].
The women in this study treated with a fixed risperidone dose of 4 mg/day had mean prolactin levels of 92 ng/ml after 12 weeks of treatment on risperidone, an elevation with potential clinical significance [ 35].
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Patients with PMP had significantly higher prolactin serum levels; male patients with PMP had a mean [S.D.] prolactin level of 705.4 uIU/ml [226.1] vs. 433.1 uIU/ml [58.4] for male patients with PMNP, while female patients with PMP had a mean prolactin level of 1890.1 uIU/ml [1138.7] vs. 978.6 uIU/ml [657.9] for female patients with PMNP.
Six women with primary hyperprolactinemia (mean prolactin level, 50 ng/ml) were matched with six normal women on eight factors influencing life style.
The baseline mean prolactin level was 5.3 ± 1.4 ng/ml, and at Week 8, the mean prolactin level was 70.0 ± 21.9 ng/ml.
However, the mean prolactin level of the nuns and their nulliparous sisters was 35% higher than that of the parous women in the sample taken approximately 1 3/4 h after rising (p less than 0.0005), and 24% higher (P less then 0.01) in the 2nd sample taken 2 h later.
However, mean serum prolactin levels for these SNPs did not vary by genotype (P-trend > 0.05).
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