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The mean pretreatment level was 10.1 pmol l−1.
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The mean pretreatment GH level was 13·5 ±3·1 µg/l, and IGF-1 (as a percentage of the value over the normal range) was 302 ± 26%.
In hyperprolactinaemic patients treated with SSTa and a dopamine agonist as first-line therapy (n = 6), the mean pretreatment GH level was 12·5 ± 2·6 µg/l, decreasing to 3·7 ± 0·9 µg/l at 1 year, and the average pretherapeutic IGF-1 level was 253 ± 35%, decreasing to 212 ± 23% at 1 year.
The mean pretreatment IL-6 level was 943 pg ml−1 (range 420 2271, standard deviation 755).
The mean pretreatment blood glucose level was significantly lower in the hypoglycemic group 5.8 ± 3.5 mmol/L (104 ± 63 mg/dL) as compared with the nonhypoglycemic group [9.0 ± 8.2 mmol/L (162 ± 148 mg/dL), P = 0.04].
The mean pretreatment blood glucose level was significantly lower in the nondiabetic patients 6.2 ± 1.9 mmol/L (111 ± 34 mg/dL) as compared with the diabetic patients [10.8 ± 10.3 mmol/L (194 ± 185 mg/dL), P < 0.001].
The mean pretreatment IGF-1 level was 302 ± 26% (expressed as a percentage of the upper limit of the normal range matched for sex and age) (Table 1), decreasing to 181 ± 14% at 6 months, to 174 ± 14% after 1 year (P < 0·01), and to 124 ± 18% after 10 years (P = 0·02).
The posttreatment INR was then regressed on the adjusted pretreatment level to allow for regression to the mean.
The mean pretreatment pure tone audiometry for all 42 animals was 39.6±6.8 dB (sound pressure level; SPL), the mean post-treatment pure tone audiometry was 43±6.9 dB.
The pretreatment level of biomarkers showed no association with downstaging.
The mean pretreatment prostate specific antigen and Gleason scores were 9.16 ng/mL and 7, respectively.
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