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Finally, combining Equations 8 and 9 with Equations 11 and 12, and multiplying by the number of loci and their mean phenotypic effect, Nδ, yields Equation 5 in the main text.
Inspired by this, we proposed several tests for associating X-linked QTLs that are based on either directly testing for the inflated phenotypic variance or accounting for it as part of the testing for mean phenotypic effect.
As the rate of environmental change v increases, the mean phenotypic effect of substitutions increases, too, but the mode may actually decrease; that is, the distribution becomes more asymmetric and skewed, resembling the "almost exponential" distribution of substitutions from de novo mutations in the sudden-change scenario (Orr 1998).
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Mutations with mean phenotypic effects smaller than 2% or with selection coefficients larger than 0.15 would likely require >100× sequencing coverage in each bulk to be mapped.
This means that strong phenotypic effects of the CAT, GPX1, GSR, GCLM, EPHX1, CYBA, and IL5 genes (they showed the similarity between the models) may be considered as major gene effects.
Unravelling gene function by large scale mutant screening has been mainly based on the mean value of a phenotypic effect measured under a given lab condition.
The TPV represents an individual's total phenotypic effect on the population mean, which equals its direct phenotypic effect plus n-1 its indirect phenotypic effect.
He illustrated his concept of genotype buffering using the phenomenon of 'phenocopying', whereby the phenotypic effect of a mutation can also be created by non-genetic means.
Haplotype effects were computed by the method of Shibata et al. (54), as the mean phenotypic values among individuals carrying one or two copies of the haplotype of interest.
Both the mean number of fixations | G | fix and the mean phenotypic distance traveled z * increase with the rate of environmental change, reflecting the fact that more and larger-effect alleles become fixed if the environment changes fast.
The mean phenotypic diversity among landraces (GST) was 0.21.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com