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Mean peak lactate dehydrogenase (LDH) was 811 U/L.
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At presentation (within first day of admission), 12,246 patients had at least one lactate determination and the median peak lactate was 1.8 (IQR 1.2 to 2.9) mmol/L.
Mean peak post-exercise (T1) lactate concentrations were 13.3 ± 1.2 mmol/l and were significantly increased compared to pre-exercise values (P < 0.0001).
The better to explore this correlation, the patient population was divided into deciles of distribution, and for each decile, the mean value of peak lactates (± standard error of the mean) was calculated.
Fasting plasma lactate concentration was 0.84 ± 0.02 mmol/L (Supplementary Fig. 1 B ). Plasma lactate began to increase 4 min after the glucose bolus, achieved its mean peak value of 1.30 ± 0.03 mmol/L at 40 min, and then declined monotonically to near basal by 120 min (0.78 ± 0.02 mmol/L).
This might explain why lactate-time-integral does not outperform peak lactate values in outcome prediction in the present cohort.
Numbers in brackets are peak lactate levels if not reached at time of admission.
We report the highest value recorded during the first 48 h as the "peak lactate".
Mean peak latency was 2.2 ± 0.2ms.
Vasoplegia was uncommon, associated with cumulative fluid balance and elevated peak lactate, and a prolonged duration of hospital stay.
Peak lactate correlated with peak adrenaline (rho = 0.34, P = 0.032).
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