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Mean peak creatinine kinase was lower in patients with diabetes.
The mean peak creatinine was higher among those with late-age onset AAV (8.2 ± 4.4, older vs 5.8±2.5.5 mg/dL, younger; p = 0.150), although this did not reach statistical significance.
Patients referred to nephrology services were statistically more likely to be younger, with pre-existing CKD and more severe AKI in association with a higher mean peak creatinine and potassium.
In the group 1 with RRT the mean peak creatinine level postoperative before starting RRT was 260±98 μmol/l, whereas in the group 2 without RRT the peak level was 136±68 μmol/l indicating that even patients without RRT developed renal failure after TPL.
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In patients with AKI, the mean peak serum creatinine was 4.17 mg/dL.
Among our patients, the mean nadir protein level (±SD) was 67±5 g/dL, and the mean peak urea and creatinine levels (±SD) were 5.1±1.7 mmol/L and 101±16 mmol/L respectively.
Postoperatively, the mean peak increase in creatinine was slightly higher in gelatin patients.
Paradoxically, in a study reported by Vogt et al. hemodialysis performed after CM administration was associated with a significantly greater mean peak in serum creatinine (P < 0.05) compared with patients who did not undergo hemodialysis [ 73, 74].
Although nephrotoxicity was greater for the 1-mg/kg/day dose, this translated into a mean difference in the peak creatinine level of 13 μmol/liter, which is of minor clinical significance and should not deter clinicians from using the more-fungicidal, higher dose.
The baseline serum creatinine value was the creatinine obtained on admission in the ICU; the peak creatinine value was considered as the highest level during the ICU stay and therefore compared with the serum creatinine on admission.
Pre-operative baseline and peak creatinine data is prospectively recorded by our audit team to monitor the incidence of AKI.
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