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Exact(16)
Only 2±1%1% of 9-AC released from the polymer conjugate was detected in the small intestine (SI), and the mean peak concentration of free 9-AC was 45-fold higher than that from released drug.
The mean peak concentration of released 9-AC in cecal contents, feces, cecal tissue, and colon tissue were, respectively, 3.2-fold, 3.5-fold, 2.2-fold and 1.6-fold higher than that using free 9-AC.
A similar plateau is observed in mean peak concentration.
Mean peak concentration (Cmax) values in plasma were about 10 μg/ml without difference between formulations.
The mean exposure concentration was 0.16 ppm (0.04 0.51) and the mean peak concentration 1.14 ppm (0.18 2.93).
Prednisolone was distributed to the aqueous humor reaching a mean peak concentration of 100.9 ± 25.5 ng/mL at 1.25 h after administration.
Similar(44)
The mean peak concentrations were 13.4, 62.3, and 146.7 μg/mL; the mean AUC0 ∞ were 30, 272, and 1204 h × μg/mL; and the mean percentages of daptomycin released were 6%, 18%, and 42% for the beads containing 2.5%, 7.5%, and 15.0% daptomycin, respectively.
However, in contrast to huKS-IL2, a dose-dependent decrease in clearance was observed with hu14.18-IL2, and both clearance and mean peak concentrations increased in cycle 2 [ 22].
Mean peak concentrations and area under the curve (AUC) were significantly higher with CPY (17 and 14%, respectively) in comparison to CM.
In animals operated on with implantation of netilmicin-loaded bone, mean peak concentrations were 4.2 [3.7 4.7] μg/mL 2-3 h postoperatively, whereas vancomycin could not be detected at all in serum.
The mean peak concentrations (Cmax) of panobinostat were 12.6, 16.6 and 15.6 ng ml−1 (Days 1, 8 and 15) at dose level 1 (n=8), which was declared the MTD (Table 3, Figure 1A).
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