The resulting optimized nanoparticles had a zeta potential, mean particle size, loading capacity and entrapment efficiency of 52.5 ± 0.5 mV, 613 ± 41 nm, 10.7 ± 0.6%, and 86.9 ± 2.6%, respectively.
SLN was further characterized for their mean particle size, loading parameters, in vitro drug release behaviour, and morphology.
Results for mean particle size, drug loading content, entrapment efficiency, and in vitro drug release of CHE-loaded O-CMCS microspheres were found to be of 12.18 μm, 4.16 ± 3.36%, 57.40 ± 2.30%, and 54.5% at pH 7.4 after 70 h, respectively.
The mean particle size of docetaxel loaded nanostructured lipid carrier (DTX-NLC), as determined by dynamic light scattering (DLS), was between 120 nm and 250 nm during the storage period of 30 days, with the entrapment efficiency decreasing from (60.5 ± 5.0)% to (55.3 ± 4.5)%, while zeta potential was slightly changed from (−43.19 ± 3.6) mV to (−40.12 ± 4.3) mV.
A 3-level factorial-response surface methodology (3LF-RSM) was used to study the effect of different variables on formulation properties like mean particle size, percentage drug loading (%DL), and entrapment efficiency (%EE) of the prepared SLNs.
The mean particle sizes of the drug loaded PLGA nanoparticles were measured by Photon Correlation Spectroscopy (PCS).
Drug microcrystals showed a narrow size distribution with approximately 2 μm mean particle size and high drug loading.
The predicted formulation was 15% APAP loading, 8.25% AMCE loading, and 400 μm mean particle diameter.
In all examined cases the mean particle sizes increase with increasing engine load.
Figure 1 Mean particle size distributions of the felodipine loaded nanoparticles (F2) measured by Dynamic laser light scattering (data as mean ± S.D; n = 6).
