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Among the NIG, 5 patients (11.9%), less exposed to zidovudine and with a higher mean of viral load, reached an FMR below 1.5.
Mean of viral titres were compared by Mann-Whitney no-parametric test, P< 0.05 (Software MedCalc® statistical software version 11.1.1.0).
The mean of viral foci number in negative control wells was 71 ± 3.5 as a base-line for the foci reduction percentage calculation.
The base-line value for the negative control of post-adsorption treatment was 69.6 ± 3.5 based on the mean of viral foci number in un-treated wells.
The base-line value for the negative control of prophylactic treatment was 76.6 ± 4 based on the mean of viral foci in un-treated wells.
Among cytological samples testing HPV-DNA positive, the mean of viral loads was 502.9 ± 620.5 RLU/CO, the median being 155.79 RLU/CO (range 1.45 2663.29 RLU/CO).
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The very early presence of viral DNA in draining lymph nodes strongly suggests that infected cells are one means of viral dissemination from the mucosa.
These results indicate that direct killing of infected cells might not be the dominant means of viral control in the chronic phase of SIV/SHIV infection.
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CEO of Professional Science Editing for Scientists @ prosciediting.com